Obstetrics and gynaecology

Prof Rodney Baber AM
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In this Product Explainer, Professor Rod Baber, a Clinical Professor of Obstetrics and Gynaecology at The University of Sydney discusses why estradiol gel should be used, how it is administered and when it should be prescribed and used (4 mins).

Dr Katrina Moss
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One-fifth of Australian women still don’t receive mental health checks both before and after the birth of their baby, our research has found. Although access to recommended perinatal mental health screening has more than tripled since 2000, thanks largely to government investment in perinatal mental health, our surveys show there is still some way to go before every mum gets the mental health screening needed.

Dr Karen Magraith
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It is said that nothing is certain but death and taxes. For women, provided they live long enough, another certainty is menopause. Most women have their final menstrual period between the ages of 45 and 55, though there are women with early menopause who have unique needs.

Dr Linda Calabresi
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Vaginismus is a surprisingly common condition, but women often fail to seek help because of embarrassment and sometimes shame, says sex and relationship expert Dr Rosie King, and the distress it causes should not be underestimated.

Prof Jane Tomnay
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Around one in six Australian women have had an abortion by their mid-30s. These women come from all age groups and demographics: some are mothers already, while others are child-free; some are partnered, others are single.Abortion was removed from the New South Wales Crimes Act in October and is now legal in all Australian states and territories, under certain circumstances.However, many women have difficulties accessing these services, especially in rural and regional areas. This needs to change.

Dr Linda Calabresi
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The majority of babies born prematurely will make it to adulthood without any major health issues, according to new research.In an extensive Scandinavian cohort study, researchers found there was a high prevalence of survival without any major comorbidities among those born prematurely, even though preterm births are known to be associated with cardiometabolic, respiratory and neuropsychiatric disorders in adulthood. There was an exception however. Outcomes were worse for those born extremely preterm (22-27 weeks).The study is important, say its authors, as most previous research has concentrated on the negative consequences of the baby not making it to term.

Kassia Beetham
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Expectant mothers receive an avalanche of information about potential risks to their baby. There’s a growing list of foods, toxins and environmental threats to avoid. It’s normal for this to lead to an increased level of anxiety.As a result, some women believe it’s safer to avoid any risks in pregnancy, no matter how small. Vigorous exercise may be considered one of these risks.But we’ve recently reviewed the research and found vigorous exercise is safe during pregnancy, including in the third trimester. And not only is it safe; it’s healthy, too.

Expert/s: Kassia Beetham
Dr Linda Calabresi
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Hormone replacement therapy has recently hit the headlines again and not in a good way. A research paper published in The Lancet reignited the controversy by again highlighting an association between hormone therapy and breast cancer.While the experts have been quick in their response, pointing out the numerous limitations of the study and the researchers’ conclusions, it is still more than likely GPs will again be grilled about the latest evidence with regard to this treatment.It’s an area of medicine that certainly has been heavily scrutinised over the past couple of decades and as such it is important GPs have ready access to the latest guidelines to best practice.Here is a great little resource that fits the bill perfectly.

Dr Linda Calabresi
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This is one of those resources you will wish you would have discovered earlier.Maternity Matters (https://maternity-matters.com.au/) is a website developed and largely authored by well-known Brisbane GP Dr Wendy Burton.As the name suggests it is reservoir of information related to pregnancy and is aimed chiefly at the general public but also provides a healthy serving of support materials for Australian health professionals as well. Dr Burton who is Chair of the Antenatal/Postnatal Specific Interest Group for the Royal Australian College of General Practitioners has compiled articles, interviews and links to important guidelines and similar reference materials on this site, that cover everything from pre-conception checklists to the post-natal issues such as vaccinations and return to exercise. This website is strongly based on evidence but is also very practical, addressing many of the more controversial and topical issues currently confronting the pregnant woman such as tongue-tie in infants and children’s risk of allergy.All the information is current and very Australian, with contributions from some very well-respected experts. As Dr Burton points out there is a lot of information out there on pregnancy and infant health - some of it very good, but, let’s face it, there’s a lot of dodgy stuff too – leaving women often confused and unnecessarily anxious. Asking patients not to Google is unlikely to be all that effective, but if patients can be directed to an authoritative, comprehensive site such as Maternity Matters you can feel confident that the information they receive will be reasonable and largely in keeping with what you, the qualified GP, would have said – if you were available at 3am when the patient was awake and seeking answers.Access the resource here

Dr Linda Calabresi
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Female patients who present with vulval pain or itch have usually put up with symptoms for some time before coming to the doctor.When it comes to this area of the female anatomy there is still a lot of ignorance and embarrassment in the world outside our surgeries. And while it is true you can find the answer to almost any question on the net, for these particular problems there’s a lot of dodgy information out there.So here’s an information source you can trust and recommend.Care down there (www.caredownthere.com.au) is a consumer-directed website written by respected health professionals that provides accurate, up-to-date and practical information and advice about all things vulval. From herpes to vulval sclerosis, the site covers the broad range of conditions that can affect women as well as providing some fundamental education about how to distinguish between normal anatomy and physiology and something going awry.The site was founded by Dr Gayle Fischer and Dr Jennifer Bradford who are well-known, well-respected members of the Australasian College of Dermatologists and the Royal Australian and the New Zealand College of Obstetricians and Gynaecologists. The content has been developed by a group of Australian health professionals with an interest and experience in vulval problems including dermatologists, gynaecologists, a pain management specialist, a sexual health physician, a psychologist and a pelvic floor physiotherapist. It is sponsored by Epiderm but exists as an independent resource.If you’re wanting to direct your female patients to a resource that is both comprehensive and authoritative, this really does fit the bill. >> Access the resource here

Dr Linda Calabresi
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Increasingly, pregnant women are heeding the warnings about the dangers of pertussis and getting vaccinated but the same does not appear to be happening with influenza protection.According to an Australian retrospective analysis, pertussis vaccination of pregnant women in Victoria increased from 38% in 2015 to 82% two years later. However, when they looked at rates of influenza vaccination the prevalence fluctuated according to the season but even so, the overall rate was only 39%.Looking first at the factors that appeared to influence whether a woman got vaccinated at all, the researchers found women who were older, who were having their first child, attended antenatal care earlier in the pregnancy and who were receiving GP-led care were more likely to receive immunisation (thumbs up for the GPs).On the negative side, the likelihood of vaccination was significantly lower in women born overseas, those who smoked during pregnancy and among Aboriginal and Torres Strait Islander women.Overall it appeared the more contact a pregnant woman had with the health system, especially if that contact was with health professionals who are well-versed in all things immunisation, ie GPs, the more likely it was that vaccination would be offered, accepted and delivered.The variation in coverage rates across different hospital-led organisations reflects the fact that immunisation for flu and pertussis has not yet become part of standard, best practice guidelines for routine antenatal care.“Fewer than half the respondents indicated that vaccines were always or usually administered during routine antenatal care,” they wrote.Following on from these general observations, researchers tried to determine why it was that vaccination coverage for pertussis rose so dramatically between 2015 and 2017, and why coverage for influenza prevention didn’t.“This may reflect continued promotion by state and national bodies of the importance of maternal pertussis vaccination, and increased awareness among pregnant women of the seriousness of pertussis in infants,” they said.By contrast, the researchers suggest that influenza is often believed to pose a greater health risk to the mother as opposed to the infant, and this along with concerns about the safety of the flu vaccine itself may, at least in part, explain the poor uptake of this vaccine.To improve this situation and increase rates of protection for Australian pregnant women and their children, the study authors had a number of recommendations.Most importantly they suggest we need to build vaccination against pertussis and influenza into the standard of care for all antenatal practices – be they hospital based, midwife-led or part of the GP antenatal shared care program. Basically we need to bring vaccination up and centre into our consciousness, so women get offered the vaccine and then ensure our systems have the capacity to be able to provide this vaccination as the opportunity arises.“Maternal vaccination should be embedded in all antenatal care pathways, and systems should be improved to increase the uptake of vaccination by pregnant women,” they conclude.Other recommendations included highlighting the benefits of vaccination to those groups of women most at risk such as women who smoke and Aboriginal and Torres Strait Islander women. But key to all the recommendations is making vaccination just part of routine care.As an accompanying editorial points out, “Embedding vaccination into standard pregnancy care, whether delivered by GPs, midwives or obstetricians, normalises the process, improves access to vaccination and reduces the risk of missing opportunities for vaccination.” 

References:

Rowe SL, Perrett KP, Morey R, Stephens N, Cowie BC, Nolan TM, et al. Influenza and pertussis vaccination of women during pregnancy in Victoria, 2015-2017. Med J Aust 2019 Jun 3; 210(10): 454-62. DOI: 10.5694/mja2.50125Marshall HS, Amirthalingam G. Protecting pregnant women and their newborn from life-threatening infections. Med J Aust 2019 Jun 3; 210(10): 445-6. DOI: 10.5694/mja2.50174
Dr Linda Calabresi
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Benzos increase the risk of having a miscarriage in early pregnancy, regardless of whether you’re taking a short-acting one for insomnia or a longer-acting one for anxiety, Canadian researchers say.According to their large case-controlled study involving almost 450,000 pregnancies, benzodiazepine exposure in early pregnancy was associated with an 85% higher risk of spontaneous abortion compared to pregnancies where that class of drugs were not taken. And this increased risk remained the same, after a whole range of possible confounders had been adjusted for, including maternal mood and anxiety disorders.But this isn’t the new bit. Previous research, including both a UK population-based study and an Israeli prospective study had confirmed the link between benzos and spontaneous abortion. In Australia, benzodiazepines have been given a Category C rating in terms of safety in pregnancy. (Drugs owing to their pharmacological effects have caused or may be suspected of causing harmful effects on the human fetus or neonate without causing malformations.)“Benzodiazepines cross the placental barrier and accumulate in the fetal circulation at levels that are one to three times higher than the maternal serum levels”, the researchers explained.What hasn’t been known, to date, is whether this is a class effect or are some benzos worse than others.Well – according to this study published in JAMA Psychiatry – ‘the risk was similar among pregnancies exposed to short-acting …and long-acting benzodiazepines during early pregnancy.’So it didn’t matter if you were prescribed long-acting clonazepam or short-acting lorazepam (interestingly the two most frequently prescribed benzos), the risk was more or less the same.“All benzodiazepine agents were independently associated with an increased risk of [spontaneous abortion],” the study authors said.In addition the study found the risk increased as the daily dose of benzodiazepines increased, suggesting a dose-response effect. So basically the more doses of benzos a pregnant woman takes, either in terms of strength or duration, the greater the risk she will miscarry.Overall, the researchers concluded that pregnant women should avoid taking benzodiazepines, and if they have to take them only take the lowest dose possible for shortest duration possible.“Alternative nonpharmacologic treatments exist and are recommended, but if benzodiazepines are needed, they should be prescribed for short durations,” they concluded. 

Reference

Sheehy O, Zhao JP, Bérard A. Association Between Incident Exposure to Benzodiazepines in Early Pregnancy and Risk of Spontaneous Abortion. JAMA Psychiatry. 2019 May 15. DOI: 10.1001/jamapsychiatry.2019.0963 [Epub ahead of print]