Sign up
Healthed-White-on-Blue

Anti-CCP and Diagnosing Rheumatoid Arthritis

Dr Daman Langguth

writer

Dr Daman Langguth

Head of the Immunology Department at Sullivan Nicolaides Pathology; Chair of Sullivan Nicolaides Pathology Partners.

Dr Daman Langguth
Dr Daman Langguth

Historical and Pathological Background

Research in rheumatoid arthritis (RA) over the past 10 years has gained significant ground in both pathophysiological and clinical understanding.

It is now known that early aggressive therapy within the first three months of the development of joint symptoms decreases the chance of developing severe disease, both clinically and radiologically.

PASSWORD RESET

Forgot your password or password not working? Please enter your email address. You will receive an email with the link to set a new password.

References

  1. ACR Position statement on anti-CCP antibodies http://www.rheumatology.org/publications hotline/1003anticcp.asp.
  2. Forslind K, Ahlmén M, Eberhardt K, Hafström I, Svensson B; BARFOT Study Group. Prediction of radiologic outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP). Ann Rheum Dis. 2004; 63(9):1090-5. DOI: 10.1136/ard.2003.014233
  3. Huizinga TW, Amos CI, van der Helm-van Mil AH, Chen W, van Gaalen FA, Jawaheer D, et al. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 Shared epitope for antibodies to citrullinated proteins. Arthritis Rheum. 2005 Nov; 52(11): 3433-8. DOI: 10.1002/art.21385
  4. Lee DM, Schur PH. Clinical Utility of the anti-CCP assay in patients with rheumatic disease. Ann Rheum Dis. 2003 Sep; 62(9): 870-4. DOI: 10.1136/ard.62.9.870
  5. van Gaalen FA1, Linn-Rasker SP, van Venrooij WJ, de Jong BA, Breedveld FC, Verweij CL et al. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis. Arthritis Rheum. 2004 Mar; 50(3): 709-15. DOI: 10.1002/art.20044
  6. Zendman AJW, van Venrooij WJ, Prujin GJM. Use and significance of anti-CCP autoantibodies in rheumatoid arthritis. Rheumatology. 2006 Jan; 45(1): 20-5. DOI: 10.1093/rheumatology/kei111
Icon 2

NEXT LIVE Webcast

:
Days
:
Hours
:
Minutes
Seconds
Dr Gabby Mahoney

Dr Gabby Mahoney

Allergen Introduction – Practical Tips for GPs

Prof Brendon Yee, A/Prof Ralph Audehm

Prof Brendon Yee, A/Prof Ralph Audehm

Obstructive Sleep Apnoea

Join us for the next free webcast for GPs and healthcare professionals

High quality lectures delivered by leading independent experts

03 February 2026
Register Now

Share this

Share this

Dr Daman Langguth

writer

Dr Daman Langguth

Head of the Immunology Department at Sullivan Nicolaides Pathology; Chair of Sullivan Nicolaides Pathology Partners.

Test your knowledge

  • Dermatology

Clinical Quick Quiz – What is the most likely diagnosis for these demarcated plaques on the trunk and limbs?

Recent articles

  • Women's health

New cervical screening guidelines: Your questions answered

  • Lifestyle

Exercising in mid and later life can reduce dementia risk – new study

  • Dermatology

Clinical Quick Quiz – What is the most likely diagnosis for these demarcated plaques on the trunk and limbs?

  • Oral and dental

Bruxism and temporomandibular disorders in GP

Latest GP poll

The government told the public that the average GP is earning $280k per year. Do you think this figure is:

Very overestimated

0%

Moderately/slightly overestimated

0%

Quite accurate

0%

Moderately/slightly underestimated

0%

Very underestimated

0%

Read the full story >>

Recent podcasts

Listen to expert interviews.
Click to open in a new tab

vaginal microbiome_2

Understanding vaginal microbiome shifts in clinical practice

Podcasts iconPodcasts
Obesity,Man,Gain,Overweight,And,Fat,Causing,To,Have,High

Heart failure and obesity – Which do we manage first?

Podcasts iconPodcasts
Kitchen,,Vegetables,And,Elderly,Couple,With,Cooking,For,Healthy,Dinner,

Malnutrition and frailty in older adults – The importance of screening and early intervention

Podcasts iconPodcasts
Blocked,Artery,Filled,With,Accumulation,Of,Fat,,Cholesterol,Plaques,,Blood

The importance of LDL control

Podcasts iconPodcasts

Find your area of interest

Next up

Browse the latest articles from Healthed.

View more
Women's health

New cervical screening guidelines: Your questions answered

Australian Centre for the Prevention of Cervical Cancer executive director Professor Marion Saville answers GPs’ questions about putting the guidelines into practice

Lifestyle

Exercising in mid and later life can reduce dementia risk – new study

For years, scientists have known that moving our bodies can sharpen our minds. Physical activity boosts blood flow to the brain, enhances neuroplasticity and reduces chronic inflammation. These processes are believed to protect against cognitive decline, including dementia.

Education by clinicians, for clinicians

Get the app

Site

Company

Connect

Legal

Discover

Healthed

CPD platform

Once you confirm you’ve read this article you can complete a Patient Case Review to earn 0.5 hours CPD in the Reviewing Performance (RP) category.

Select ‘Confirm & learn‘ when you have read this article in its entirety and you will be taken to begin your Patient Case Review.

Cancel
Confirm & learn

Save $160 when you register for a 2026 seminar today!

You're invited to attend the Women's & Children's Health Update 2026, Australia's most popular seminar for GPs and healthcare professionals. Secure your seat to a seminar in a city near you!

Register for $135
WCH26 - Carousel Ad - MWCH26 date
WCH26 - Carousel Ad - SWCH26 date
WCH26 - Carousel Ad - BWCH26 date
WCH26 - Carousel Ad - PWCH26 date
WCH26 - Carousel Ad - AWCH26 date