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Dr Linda Calabresi

A single 30minute educational session with a physio about post-op breathing exercises prior to elective upper abdo surgery, halves that patient’s risk of respiratory complications compared with usual care, Australian research shows. The randomised study conducted among 441 patients across three hospitals in Australia and New Zealand showed the pre-op intervention reduced the risk of post-operative pulmonary complications from 27% in the control group to 12% in the physio-taught group. In fact, the number need to treat to prevent one such complication was only seven. The effect was greatest in men, those undergoing colorectal surgery, those aged under 65 and those educated by an experienced physiotherapist. So what did this all-important physio session involve? Well, as they say in the classics – it wasn’t rocket science. The physiotherapists had a standard script which included educating the patient about the high likelihood of a pulmonary complication following this type of surgery (10 to 50% according to the literature) and the importance of early ambulation as well as breathing exercises in preventing these. Many patients are unlikely to up and about in the first couple of days following major upper abdominal surgery but at least the breathing exercises can be done from the moment the patient regains consciousness – two sets of 10 slow, deep breaths followed by three coughs, using an abdominal support pillow to reduce pain. And this is to be repeated hourly. This was emphasised in the education session which was conducted at some stage in the six weeks prior to surgery. The physio session also included a practice run through of these exercises. However, interestingly the control group also received pre-op written information about these same facts and exercises, and were reminded of them post-op as part of standard care. What then made the difference? “One explanation for the effectiveness of pre-operative physiotherapy to reduce [post-operative pulmonary complications] is that the preparation, motivation and training of the patient before surgery brings the timing of breathing exercise initiation to immediately after regaining consciousness after surgery,” the study authors suggested. A degree of atelectasis is common with this type of surgery and general anaesthetic. The immediate commencement of these exercises could facilitate the re-inflation of the lungs, and prevent the progression of this atelectasis. The primary end point of this study was the development of one or more of seven respiratory symptoms or signs in the 14 days post op including chest xray evidence of consolidation or collapse, cough with coloured sputum or a respiratory-related high white cell count. One of the secondary endpoints was pneumonia, the relative risk of which was reduced by 52% courtesy of the intervention. In essence, the study showed how the right education and motivation given at the right time can dramatically improve health outcomes with results that are directly applicable to tens of millions of patients awaiting surgery such as this worldwide. “[P]atients reported that pre-operative physiotherapy empowered them to treat themselves and placed high value on its role in improving their post-operative recovery,” the researchers said. Ref: BMJ 2018;360:j5916 doi:10.1136/bmj.j5916

Prof Graeme Suthers

Despite potential savings of more than $1 billion annually, awareness of pharmacogenomic tests among Australian prescribers is low and national guidelines for their use have not been developed. This void contributes directly to the continued prescribing of ineffective medications, unacceptably high rates of adverse drug reactions and associated personal and economic costs. Pharmacogenomics (PGx) is the study of how the genome of an individual patient influences their response to a medication.

Vasu Appanna

Bacteria are at the centre of all life forms on planet earth and are the essential building blocks that make living organisms the way they are. Both the mitochondrion — found in most organisms, which generates energy in the cell — and the chloroplast — the solar energy-harvester located in plants — can be traced to their bacterial ancestors. These specialized microbes laid the foundation for the biodiversity we live amongst.

Prof Deborah Bateson

Fertility awareness apps are being championed as a new approach to contraception. In reality, while the technology may be new, women have been predicting the fertile days in their menstrual cycles to prevent pregnancy for a very long time. But the growth of the “femtech” industry, alongside a seemingly growing wave of younger women looking to move away from hormonal methods of contraception, has led to a renewed interest.

Dr Linda Calabresi

Did you know that melanoma is the most common malignancy in pregnancy? It accounts for one third of pregnancy-associated malignancies in Australia. Terrifying stuff isn’t it? Fortunately, melanoma occurring in a pregnant woman remains a very rare occurrence. But no one wants to be the doctor that misses it, especially as we all know picking it up early can, quite literally, be the difference between life and death. The really tricky part is that pregnancy does add an extra dimension to detecting and managing melanoma. For a start melanocytic naevi darken during pregnancy in one in ten women.

Dr Linda Calabresi

Cancer Council NSW has developed a fantastic new podcast series specifically for patients with advanced cancer. The series, entitled ‘The Thing About Advanced Cancer’ provides evidence-based information and practical tips for this group of patients who are often hungry for answers and guidance beyond the usual facts and statistics currently available for their condition.

Dr Linda Calabresi

In the ‘largest analysis to date’, researchers have determined that subclinical hypothyroidism is associated with preterm birth but have stopped short of recommending screening. It is well-known that overt thyroid disease in pregnancy is linked with preterm birth, as defined as delivery before 37 weeks. But whether milder forms of thyroid disease make a difference has been controversial.

Dr Lawrie Bott

Glomerular filtration rate (GFR) is the best single measure of kidney function. A subnormal GFR is an important early indicator of possible chronic kidney disease. However, it also does not identify the cause. It is also not a ‘catch all’, for example, in early diabetes mellitus, GFR will typically be normal or even increased, due to ‘hyperfiltration’. Optimal detection and risk stratification of early kidney disease also requires measurement of urine albumin, rather than just eGFR.

Dr Linda Calabresi

While the ‘opioid epidemic’ might be grabbing all the headlines at the moment, Australian toxicologists are reminding us that paracetamol is the most common drug used in overdoses in this country. What’s more the numbers of both paracetamol-related hospital admissions and liver injury have been increasing over the past decade at a rate that far exceeds the rate of population increase. According to a retrospective study recently published in The Medical Journal of Australia, there has been an average 3.8% annual increase in the number of paracetamol-related hospital admissions since 2007, and a mean 7.7% annual increase in paracetamol-related liver injury cases, whereas the population has been increasing at a rate of only 1.6% annually.

Dr Lawrie Bott

Elevated potassium is one of the most vexing problems faced by a clinician because of the difficulty knowing whether an elevated level (for example, 7.5mmol/L) is a harmless artefact or imminently lethal hyperkalaemia. The clinical background is critical to interpretation.

Dr Linda Calabresi

Here is a useful resource for those GPs who have patients who are struggling with issues related to their sexuality and need more specifically tailored support. Even though there is much more awareness and openness about different sexual orientations, it is likely GPs will appreciate the support of this free counselling and referral service developed for people who are LGBTI.

Helen Rawson

This week, the aged care royal commission looks at diversity in aged care, an issue becoming increasingly relevant to both residents and the staff who care for them. Diversity includes gender, sexual orientation, religion and social background. The issue is important because if we aim to offer older people and families choice and control in aged care, we must meet the diverse needs of all older people. Australia’s rich diversity is reflected in its older population. In 2016, more than one-third (37%) of Australians aged 65 and over were born overseas and one-fifth (20%) were born in a non-English speaking country. These figures have increased continually since 1981, when one-quarter (25%) of older people were born overseas.